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Journal of Bone and Joint Surgery, 1973;55:606-612.
© 1973 by The Journal of Bone and Joint Surgery, Inc

Heparin Osteoporosis

AN EXPERIMENTAL MODEL USING RATS

ROBY C. THOMPSON JR. M.D.1

1 From the Department of Orthopaedics, University of Virginia Medical Center, Charlottesville

Rats injected subcutaneously with heparin daily for eight weeks (clotting time about twice normal for twelve hours daily) showed a decrease in breaking strength of the humerus of about 8 per cent, a decrease in the cross-sectional area of the humeral cortex of about 12.5 per cent and a decrease in the amount of bone collagen synthesis of about 20 per cent as compared with the controls.


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