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Journal of Bone and Joint Surgery, 1973;55:595-605.
© 1973 by The Journal of Bone and Joint Surgery, Inc

Multiple Metachronous Osteogenic Sarcoma

REPORT OF TWELVE CASES WITH TWO LONG-TERM SURVIVORS

ROBERT H. FITZGERALD JR. M.D.1, DAVID C. DAHLIN M.D.1, and FRANKLIN H. SIM M.D.1

1 From the Departments of Orthopedics and of Surgical Pathology, Mayo Clinic and Mayo Foundation, Rochester

Twelve patients who had multiple osteosarcomas without intervening visceral lesions differed sharply from those patients whose multifocal osteosarcomas seemed to arise synchronously. It was not possible to determine whether the metachronous sarcomas represented late metastases or new primary tumors. The significant observation was that patients who had a new lesion were potentially curable. Surgical therapy produced two long-term survivors in the group of twelve patients.


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