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Journal of Bone and Joint Surgery, 1973;55:287-300.
© 1973 by The Journal of Bone and Joint Surgery, Inc

A Visual, Histological, and Enzymatic Study of Regenerating Rheumatoid Synovium in the Synovectomized Knee

MICHAEL J. PATZAKIS M.D.1, DAVID M. MILLS M.D.1, BRUCE A. BARTHOLOMEW M.D.1, MACK L. CLAYTON M.D.1, and CHARLEY J. SMYTH M.D.1

1 From the Department of Medicine, Division of Rheumatic Diseases, and the Department of Surgery, Division of Orthopedic Surgery, University of Colorado Medical School, University of Colorado Medical Center, Denver

In the knees of twenty-five patients with rheumatoid arthritis who had had synovectomy an average of thirty-one months previously (range one to 120), arthroscopy, aspiration, and biopsy were done. The findings were that the regenerated synovium became histologically indistinguishable from that found in patients not operated on—grossly and microscopically active areas alternated with inactive ones, lysosomal glycosidases were elevated and rose with time, and the synovium of eighteen of twenty-one of the patients two years after synovectomy met the criteria for rheumatoid disease.


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