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Journal of Bone and Joint Surgery, 1973;55:169-176.
© 1973 by The Journal of Bone and Joint Surgery, Inc

Acute Candida Arthritis

REPORT OF A CASE AND USE OF AMPHOTERICIN B

FRANK R. NOYES M.D.1, JOHN D. MCCABE M.D.1, and F. ROBERT FEKETY JR. M.D.1

1 From the Section of Orthopaedic Surgery and Division of Infectious Disease, University of Michigan Medical Center, Ann Arbor

A case of Candida infection of the knee and probably also of the hip is reported, emphasizing the predisposing factors in its genesis. A treatment program using a bioassay of amphotericin B concentrations in the serum and joint aspirate is discussed. This allows use of a dose lower than usually recommended and avoids the more toxic dose-related side effects. Amphotericin B administered systemically penetrated the joint in therapeutic levels. Systemic treatment and repeated aspirations produced a prompt response obviating the need for surgical drainage.


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