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Journal of Bone and Joint Surgery, 1972;54:1367-1397.
© 1972 by The Journal of Bone and Joint Surgery, Inc

Immunologic Aspects of Osteosarcoma and Their Application to Therapy

A PRELIMINARY REPORT

BURTON MARSH M.D.1, LEO FLYNN M.D.1, and WILLIAM ENNEKING M.D.1

1 From the W. Thaxton Springfield Center for Orthopaedic Study and Research, Division of Orthopaedic Surgery, University of Florida, Gainesville

Data are presented that demonstrate the antigenicity of saline extracts of normal bone and osteosarcoma. The tumor specificity of certain antigen(s) in the tumor extract was shown utilizing absorption techniques and tumor-specific antisera.

Attempts to alter the clinical course of a patient's disease with metastatic osteosarcoma by active or passive immunization were unsuccessful.

A method for obtaining and transferring lymphocytes sensitized to an implanted allogenic human osteosarcoma has been described. The tumor implants were rejected without apparent harm to the recipients. Although the follow-up period is short and the number of patients is small, the initial impression that transfer of sensitized lymphocytes may favorably influence the course of the disease justifies further investigation.


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