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Journal of Bone and Joint Surgery, 1971;53:1415-1425.
© 1971 by The Journal of Bone and Joint Surgery, Inc

Studies of Patients with Osteogenesis Imperfecta

JAMES A. ALBRIGHT M.D.1 and JEROME A. GRUNT M.D.1

1 From the Yale University School of Medicine, Departments of Orthopaedic Surgery and Pediatrics, The Newington Children's Hospital, Newington, Connecticut, and the Yale-New Haven Hospital, New Haven

Twenty children and five adults with osteogenesis imperfecta were studied for one year or more, and thirteen of the patients were treated with sodium fluoride (0.25 to 0.90 milligrams fluoride per kilogram of body weight per day). No significant abnormality of calcium, phosphorus, nitrogen, magnesium, or potassium balance, serum chemistries, urinary amino acid excretion, or calcium dynamics was detected before treatment, nor were changes seen during treatment. The over-all results do not warrant the general use of fluoride for the treatment of osteogenesis imperfecta but do warrant further study, especially of the dose-related effect.


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