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Journal of Bone and Joint Surgery, 1971;53:729-741.
© 1971 by The Journal of Bone and Joint Surgery, Inc

Phagocytosis of Colloidal Gold by Cells of Synovial Membrane

WAYNE O. SOUTHWICK M.D.1 and KLAUS G. BENSCH M.D.1

1 From the Section of Orthopaedic Surgery, Yale University School of Medicine, New Haven, and the Department of Pathology, Stanford University School of Medicine, Palo Alto

Phagocytosis of colloidal particles by cells of the synovial membrane has been studied in rabbits at intervals of ten minutes, twenty-five minutes, forty minutes, one hour, two hours, and three hours after injection into the joint cavity. Phagocytosis begins within thirty minutes, and it is marked within one hour. All stages of the phagocytic and digestive process were observed; this activity was particularly pronounced in the vacuolated synovial lining cells. Cells rich in endoplasmic reticulum were also engaged in phagocytosis, although to a lesser degree, and cells which apparently are the precursors of these cells were also encountered. A third cell type, with an electron-dense nucleus, was also seen. The possible relationship of these cells to one another is discussed.

This study also confirms previous reports of the discontinuity of the synovial membrane, which, in rabbits, contains small gaps between the synovial lining cells.


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