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Journal of Bone and Joint Surgery, 1970;52:1603-1610.
© 1970 by The Journal of Bone and Joint Surgery, Inc

Intra-articular Thio-tepa Compared with Depo-medrol and Procaine in the Treatment of Arthritis

ANTHONY G. GRISTINA M.D.1, NICHOLAS A. PACE M.D.1, THOMAS G. KANTOR M.D.1, and WALTER A. L. THOMPSON M.D.1

1 New York University Medical Center, University Hospital, 560 First Avenue, New York, N. Y. 10016

A double-blind comparison of intra-articular Thio-tepa, Depo-medrol, and procaine was performed in thirty-nine patients with inflammatory arthritis. Thio-tepa demonstrated a slight superiority, but the potential adverse systemic effects of the drug may not warrant its use. However, no such effects were noted in this study despite a dose of sixty milligrams. Medical synovectomy was not a demonstrable result of this treatment.


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