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Journal of Bone and Joint Surgery, 1970;52:1424-1432.
© 1970 by The Journal of Bone and Joint Surgery, Inc

Bone and Joint Perfusion with Antibiotics in the Treatment of Experimental Staphylococcal Infection in Rabbits

ALEX FINSTERBUSCH M.D.1, MEIR ARGAMAN PH.D.1, and THEODORE SACKS M.B.CH.B., M.MED (PATH.), M.R.C.PATH.1

1 From Departments of Orthopaedics and Clinical Microbiology, Hadassah University Hospital, and Hebrew University—Hadassah Medical School, Jerusalem

The development of collateral circulation through the venous channels of bone was demonstrated in the hind legs of rabbits by infusion under pressure while the proximal venous outflow was obstructed by tourniquet.

Experimental staphylococcal arthritis and osteomyelitis were treated by antibiotics administered by perfusion, with a lower mortality rate and much greater chance of sterilizing the local lesion, when compared with systemic treatment.

It is suggested that this method may be of value in the treatment of human infectious.


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