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Journal of Bone and Joint Surgery, 1970;52:1131-1137.
© 1970 by The Journal of Bone and Joint Surgery, Inc

Elevation of the Serum Alkaline Phosphatase Coincident with Ectopic-Bone Formation in Paraplegic Patients

ROBERT FURMAN M.D.1, JOHN J. NICHOLAS M.D.1, and LEO JIVOFF M.D.1

1 From the Upstate Medical Center, State University of New York, Syracuse

Fifteen paraplegic patients were followed to determine the onset, course, and remissions of ectopic-bone formation. Ectopic-bone formation occurred in seven patients and was accompanied by elevations of the serum alkaline phosphatase. In the eight patients in whom ectopic-bone formation did not occur there were no significant elevations of the serum alkaline phosphatase. It is felt, therefore, that the serum alkaline phosphatase is a reliable sign of the onset and remission of ectopic-bone formation in paraplegic patients.


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