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Journal of Bone and Joint Surgery, 1969;51:875-890.
© 1969 by The Journal of Bone and Joint Surgery, Inc

The Parafollicular Cell of the Thyroid Gland as the Source of an Osteoblast-Stimulating Factor

EVIDENCE FROM EXPERIMENTALLY OSTEOPETROTIC MICE

SANDY C. MARKS JR. D.D.S., PH.D.1

1 From the Department of Anatomy, Johns Hopkins School of Medicine, Baltimore

This investigation of experimentally produced osteopetrosis has produced evidence which suggests that the parafollicular cell is the source of an osteoblast-stimulating factor which is released during periods of hypercalcemia and which has a net effect on bone antagonistic to that of parathyroid hormone. This experimentally induced overproduction of an osteoblastic stimulus in infant mice results in hyperplasia of the osteoblastic endosteum, a dramatic increase in the capacity to incorporate 3H-proline into bone matrix, and an accumulation of bone producing osteopetrosis. Differentiation of this factor from thyrocalcitonin cannot be made on the basis of evidence Obtained to date.


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