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Journal of Bone and Joint Surgery, 1969;51:456-466.
© 1969 by The Journal of Bone and Joint Surgery, Inc

The Chemical Anatomy of Bone

I. A COMPARATIVE STUDY OF BONE COMPOSITION IN SIXTEEN VERTEBRATES

ROBERT M. BILTZ B.S.1 and EDMUND D. PELLEGRINO M.D.1

1 From the Department of Medicine, Health Sciences Center, State University of New York, Stony Brook

1. Normal variations in the elementary composition of cortical bone from sixteen different adult vertebrates were studied.

2. Variations in the mineral (ash) and water content of bone exhibited what could be a necessary reciprocal relationship.

3. The mineral components, calcium, phosphorus and magnesium were positively correlated with hexosamine (ground substance) and negatively correlated with OH-proline (collagen).

4. Although positively correlated, the variations in total CO2, sodium and citric acid were much less specific.

5. All specimens exhibited a Ca/P molar ratio of 1.67 or larger depending on the amount of CaCO3 present.

6. These differences in bone composition undoubtedly have physiological significance and their further elucidation is necessary for the valid interpretation of experimental data in all areas of mineral metabolism.


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