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Journal of Bone and Joint Surgery, 1968;50:1577-1590.
© 1968 by The Journal of Bone and Joint Surgery, Inc

Aseptic Necrosis Following Renal Transplantation

RICHARD L. CRUESS M.D., F.R.C.S.(C)1, JOHN BLENNERHASSETT M.B., CH.B., M.R.A.C.P.1, F. ROBERT MACDONALD M.D., C.M.1, LLOYD D. MACLEAN M.D., F.R.C.S.(C)1, and JOHN DOSSETOR M.D., PH.D., F.R.C.P.(C)1

1 From the Royal Victoria Hospital and McGill University, Montreal

In twenty-seven patients who survived for six months or longer following renal homotransplantation, osseous changes developed in ten patients. Nine demonstrated aseptic necrosis of the femoral head, five had involvement of the hips alone, five showed aseptic necrosis at the knee joint, and two had aseptic necrosis of the humeral heads. The average time after transplantation when symptoms arose was seven months and the roentgen changes usually were seen two months later. The etiological explanation based on fatty embolization is theoretically satisfactory but unproved.


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