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Journal of Bone and Joint Surgery, 1967;49:1227-1231.
© 1967 by The Journal of Bone and Joint Surgery, Inc

ELASTOSIS IN CHRONIC ACIDOSIS: EXTENSIVE CALCIFICATION IN TENDONS AND SOFT TISSUES

KEVIN J. MURPHY M.R.A.C.P.1 and IAN MCPHEE M.S.1

1 Princess Alexandra Hospital, Ipswich Road, Woolloongabba, S.2, Queensland, Australia

This is a follow-up report of a patient who was originally reported because of the associations of chronic renal failure and acidosis with elastic-staining fibers in tendon. The patient lived another twenty months, with acidosis only partly corrected; extensive but inconstant calcification developed in subcutaneous tissues and tendons. At autopsy he also had calcification in viscera, usually in areas of positive staining to elastic stains or periodic acid-Schiff stain, or both.

Some aspects of soft-tissue calcification are reviewed, and the suggestion offered that prolonged acidosis can lead to changes in tissue protein which favor calcium deposition.


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