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Journal of Bone and Joint Surgery, 1967;49:903-914.
© 1967 by The Journal of Bone and Joint Surgery, Inc

The Effect of Reduced Barometric Pressure on Fracture Healing in Rats

JOHN T. MAKLEY M.D.1, KINGSBURY G. HEIPLE M.D.1, SAMUEL W. CHASE PH.D.1, and CHARLES H. HERNDON M.D.1

1 From the Division of Orthopaedic Surgery, Western Reserve University School of Medicine, and University Hospitals of Cleveland, Cleveland

Fracture healing in a series of fractures of the fibula in Fischer rats was studied at a simulated altitude of 18,000 feet in both acclimatized and unacclimatized animals.

The acclimatized animals healed their fractures as well as control animals did, but there was significant retardation of fracture healing in the unacclimatized animals, up to thirty and forty days.


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