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Journal of Bone and Joint Surgery, 1966;48:1145-1155.
© 1966 by The Journal of Bone and Joint Surgery, Inc

The Influence of Immobilization and Motion on the Formation of Fibrocartilage in the Repair Granuloma after Joint Resection in the Rabbit

VERT MOONEY M.D.1 and ALBERT B. FERGUSON JR. M.D.2

1 Rancho Los Amigos Hospital, 7601 East Imperial Highway, Downey, California 90240
2 125 DeSoto Street, Pittsburgh, Pennsylvania 15213

1. Arthroplasties of the first metatarsophalangeal joints in rabbits have been examined histologically after varying periods of immobilization and subsequent motion.

2. In this laboratory model, motion started one week after surgery consistently produced the best joint as evidenced by histological examination.

3. The proposition is presented that wound repair should be looked upon as an inflammatory response and that by proper control of local factors at the wound site it should be possible to direct the tissue response into channels leading to the formation of the desired mature tissue.


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