Journal of Bone and Joint Surgery, 1965;47:785-872.
© 1965 by The Journal of Bone and Joint Surgery, Inc
Quantitative Microradiographic Studies of Normal and Osteoporotic Bone
JENIFER JOWSEY D. PHIL.1,
PATRICK J. KELLY M.D.1,
B. LAWRENCE RIGGS M.D.1,
ANTHONY J. BIANCO JR. M.D.1,
DONALD A. SCHOLZ M.D.1, and
J. GERSHON-COHEN M.D.1
1 From the Mayo Clinic and Mayo Foundation, Sections of Surgical Research (Orthopedics), Orthopedic Surgery, and Medicine, Rochester, and the Albert Einstein Medical Center, Philadelphia
Quantitative microradiography has been developed for studying bone turnover and has been applied to a study of normal and osteoporotic human bone. Evidence is presented that this method is reproducible and provides an accurate measure of bone formation and resorption. It was demonstrated that bone from the majority of osteoporotic patients differs from normal bone by an increase in the amount of resorption. Bone formation levels are generally normal; however, in Cushing's syndrome, after corticosteroid therapy, and after immobilization, bone formation decreases.