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Journal of Bone and Joint Surgery, 1965;47:349-374.
© 1965 by The Journal of Bone and Joint Surgery, Inc

The Roentgenographic Development of Radiostrontium (Sr90)- Induced Osteogenic Sarcoma in the Rat

THOMAS W. POZNANSKI M.A.1, SAM FRANKEL PH.D.1, and MARVIN DAVIS 1

1 216 South Kingshighway, St. Louis, Missouri 63110

1. The development of the roentgenographic changes associated with radiostrontium (Sr90)-induced osteogenic sarcomata in the young adult rat is described. Macroscopic and histological features of these neoplasms are also discussed.

2. Intraperitoneal administration of 0.75 microcurie of Sr90 per gram of body weight causes an incidence of osteogenic sarcoma of 65 per cent.

3. The greatest percentage of neoplasms (58.8 per cent) occurred in the spine, followed by 28 per cent in the long bones.

4. The roentgenographic characteristics of Sr90-induced osteogenic sarcomata in the rat and mouse are compared.


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