This Article
Right arrow Full Text (PDF)
Right arrow Letters to the Editor: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when Letters to the Editor are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to My File Cabinet
Right arrow Download to citation manager
Right arrowReprints and Permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by AHLBERG, A.
Right arrow Articles by BAUER, G. C. H.
Right arrow Search for Related Content
PubMed
Right arrow Articles by AHLBERG, A.
Right arrow Articles by BAUER, G. C. H.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Technorati  
What's this?
Journal of Bone and Joint Surgery, 1965;47:323-332.
© 1965 by The Journal of Bone and Joint Surgery, Inc

Use of Antihemophilic Factor (Plasma Fraction I-0) during Correction of Knee-Joint Deformities in Hemophilia A

REPORT OF THREE CASES INCLUDING ONE OSTEOTOMY

ÅKE AHLBERG M.L.1, INGA MARIE NILSSON M.D.1, and GÖRAN C. H. BAUER M.D.1

1 From the Departments of Orthopaedics and Medicine, University of Lund, Allmänna Sjukhuset, Malmö

Three cases of chronic knee-joint contractures in patients with severe hemophilia A were corrected to near full extension without significant hemorrhage by using a human antihemophilic factor concentrate, fraction I-0, prepared by the glycine method of Blombäck and Blombäck. The amount of substitution needed was adjusted on the basis of serial determinations of the antihemophilic factor concentration in the patient's plasma. The flexion contractures were corrected by skin traction for two to three weeks followed by an extension brace for a few more weeks. In one of these patients, a supracondylar wedge osteotomy was subsequently done to correct a 30-degree valgus deformity of the knee. Prior to intervention, the children were unable to walk. Postoperatively they could walk unaided and even cycle and ski despite persistent limitation or absence of knee flexion.

It is emphasized that adequate substitution therapy in hemophilia, based on serial determinations of the plasma antihemophilic factor levels, is now feasible.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Technorati Technorati    What's this?