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Journal of Bone and Joint Surgery, 1963;45:1423-1438.
© 1963 by The Journal of Bone and Joint Surgery, Inc

Epiphyseal Avascular Necrosis and Its Relation to Longitudinal Bone Growth

H. ROBERT BRASHEAR JR. M.D.1

1 From the Division of Orthopaedics, Department of Surgery, University of North Carolina School of Medicine, Chapel Hill

This is a study of the effect of epiphyseal avascular necrosis on longitudinal growth at the distal end of the femur of the rat. The findings demonstrate that proliferation of epiphyseal cartilage cells, and hence longitudinal growth, depends on an adequate epiphyseal circulation. Necrosis of the epiphysis causes marked change in the epiphyseal plate. These changes consist in walling off of the growth plate with bone and destruction of the epiphyseal cartilage. In the distal end of the femur of the rat this process appears to be irreversible.


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