This Article
Right arrow Full Text (PDF)
Right arrow Letters to the Editor: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when Letters to the Editor are posted
Right arrow Alert me if a correction is posted
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to My File Cabinet
Right arrow Download to citation manager
Right arrowReprints and Permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by PAPPAS, A. M.
Right arrow Articles by COHEN, J.
Right arrow Search for Related Content
PubMed
Right arrow Articles by PAPPAS, A. M.
Right arrow Articles by COHEN, J.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Technorati  
What's this?
Journal of Bone and Joint Surgery, 1963;45:765-772.
© 1963 by The Journal of Bone and Joint Surgery, Inc

The Abscopal Effect of X-irradiation on Bone Growth in Rats

ARTHUR M. PAPPAS M.D.1 and JONATHAN COHEN M.D.1

1 From the Departments of Orthopedic Surgery and Pathology and Division of Laboratories and Research, Children's Hospital Medical Center and Harvard Medical School, Boston

1. Four hundred roentgens of x-irradiation to an entire hind limb of young rats is sufficient to retard growth of the bones directly irradiated.

2. Eight hundred roentgens to an entire hind limb of rats retards bone growth in the area of direct irradiation and, abscopally, retards skeletal and somatic growth.

3. Eight hundred roentgens to the knee area of one extremity retards the growth of bone directly irradiated, but does not produce a demonstrable abscopal effect on skeletal growth.

4. Seventy-two days after irradiation, the weights of the rats that received 800 r to an entire hind extremity revealed a mean decrease of thirty-four grams compared with the mean weight of the control rats. The animals that received 800 r to the knee area or 400 r to the hind extremity exhibited a weight decrease of approximately twenty grams compared with the mean weight of the controls.

5. The severity of the abscopal effect is related to the dosage of irradiation administered and to the volume of tissue exposed to the irradiation.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Technorati Technorati    What's this?