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Journal of Bone and Joint Surgery, 1963;45:391-405.
© 1963 by The Journal of Bone and Joint Surgery, Inc

Osteoporosis, Osteomalacia, and the Skeletal System

JAMES A. NICHOLAS M.D.1, PAUL D. SAVILLE M.D.2, and FELIX BRONNER PH.D3

1 Director, Metabolic Bone Disease Service, Hospital for Special Surgery; Assistant Professor of Clinical Surgery (Orthopedics), Cornell University Medical College, New York, N.Y.
2 Director, Metabolism Unit, Hospital for Special Surgery; Assistant Physician to Out-Patient Department, Hospital for Special Surgery, New York, N.Y.
3 Director, Laboratory for Mineral Metabolism Bicknell Fellow Research Department, Hospital for Special Surgery; Assistant Professor of Biochemistry, Cornell University Medical College, New York, N.Y.

Osteomalacia and rickets are disorders of bone mineralization. There are many causes, but all may be controlled by suitable treatment. Except in vitamin-D deficiency, treatment often must be continued for years with careful chemical and clinical control. Relatively simple investigations enable one to distinguish between the various causes.


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