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Journal of Bone and Joint Surgery, 1962;44:682-688.
© 1962 by The Journal of Bone and Joint Surgery, Inc

Localization of Tritiated Thymidine in Articular Cartilage of Rabbits

I. Growth In Immature Cartilage

Henry J. Mankin M.D.1

1 Department of Orthopedic Surgery, University of Pittsburgh, Pittsburgh

1. Autoradiography after the administration of tritiated thymidine is an excellent tool for the qualitative demonstration of cellular reproduction. After intra-articular administration, there is a high degree of penetration of the label into the cartilage at the distal end of the femur.

2. In the immature rabbit, thymidine localization in the cartilaginous epiphysis occurs in two distinct layers, one subjacent to the articular surface and one in relation to the ossific nucleus of the epiphysis.

3. It is suggested that these two layers represent sites of interstitial growth of the cartilaginous epiphysis. The layers subjacent to the articular surface contribute to growth of the articular surface and the deeper layer contributes to the growth of the ossific nucleus of the epiphysis.


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