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Journal of Bone and Joint Surgery, 1961;43:679-686.
© 1961 by The Journal of Bone and Joint Surgery, Inc

Skeletal Changes in Suckling Rats Induced by Prolonged Papain Administration

Leonard Merkow M.S.1 and Joseph J. Lalich M.D.1

1 Department of Pathology, University of Wisconsin Medical School, Madison

A crude papain suspension when injected intraperitoneally into suckling rats for twenty-three to sixty-nine days produced malformation of the sternum, rib cage, vertebral column, and caudad ribs. Permanent cartilaginous disorganization and epiphyseal-plate closure resulted in shortened long bones and vertebral bodies. Rigidity of the vertebral column was produced by degeneration of the nucleus pulposus, characterized by precipitation of eosinophilic necrotic debris and final replacement by hyaline fibrocartilage.


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