This Article
Right arrow Full Text (PDF)
Right arrow Letters to the Editor: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when Letters to the Editor are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to My File Cabinet
Right arrow Download to citation manager
Right arrowReprints and Permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Silberberg, R.
Right arrow Articles by Silberberg, M.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Silberberg, R.
Right arrow Articles by Silberberg, M.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Technorati  
What's this?
Journal of Bone and Joint Surgery, 1961;43:243-248.
© 1961 by The Journal of Bone and Joint Surgery, Inc

Male Sex Hormone and Osteo-Arthrosis in Mice

Ruth Silberberg M.D.1 and Martin Silberberg M.D.1

1 Department of Pathology, Washington University School of Medicine, St. Louis

Male mice of strain C57BL Jax6 were treated with small doses of testosterone during growth and observed to the age of eighteen months. In mice thus treated, aging changes in the joints were accelerated and the incidence of osteo-arthrosis was significantly increased, as compared with conditions established in untreated mice. The results reported thus provide additional evidence for the importance of aging changes in the development of deforming arthrosis. The aging and arthrosis-promoting effects of testosterone are thought to be related to its growth-promoting effect and therefore to its protein-anabolic action. The male sex hormone thus seems to be responsible for the higher susceptibility of the male mouse to degenerative joint disease as compared with that of the female.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Technorati Technorati    What's this?