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Journal of Bone and Joint Surgery, 1960;42:1349-1380.
© 1960 by The Journal of Bone and Joint Surgery, Inc

A Study of Strontium85 Metabolism in the Normal and in the Castrated Mouse

Lee J. Cordrey M.D.1, James H. Christie M.D.1, William J. Macintype Ph.D.1, and Rufus Palmer B.S.1

1 Radioisotope Laboratory, Highland View Hospital, Cleveland

Variation of as little as 10 per cent in the age of animals employed in radioactive strontium studies produces significant alteration in retention of the isotope.

As would be anticipated there is calcium loss from mouse bone after castration.

There is retention of radioactive strontium in castrated mice to a degree comparable with calcium loss. This would suggest the hetero-ionic replacement of calcium ions by strontium ions.


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