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Journal of Bone and Joint Surgery, 1960;42:165-172.
© 1960 by The Journal of Bone and Joint Surgery, Inc

Sulphate Metabolism in Cartilage

II. S35-Sulphate Uptake and Total Sulphate in Cartilage Slices

Rose Robyns Coelho Ph.D.1 and O. Donald Chrisman M.D.1

1 Department of Orthopaedic Surgery, School of Medicine, Yale University, New Haven

Comparison of uptake of S35 sulphate and total sulphur sulphate in cartilage strips incubated in Krebs-Ringer's solution indicates that over-all breakdown of chondroitin sulphate is taking place despite vigorous uptake of S35.

S35 uptake is inhibited by cyanide and iodoacetate; however, cyanide protects against total sulphate sulphur loss while iodoacetate has no effect or may even increase the loss.

The existence of a cyanide-sensitive enzyme responsible for one of the early steps in cartilage breakdown is suggested.


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