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Journal of Bone and Joint Surgery, 1959;41:1482-1488.
© 1959 by The Journal of Bone and Joint Surgery, Inc

Immunological Factors in Homogenous-Bone Transplantation

III. The Inability of Homogenous Rabbit Bone to Induce Circulating Antibodies in Rabbits

Paul H. Curtiss JR. M.D.1, A. E. Powell PH.D.1, and Charles H. Herndon 1

1 Department of Orthopaedic Surgery and the Department of Surgery of the Western Reserve University School of Medicine and the University Hospitals of Cleveland, Cleveland

Groups of rabbits were injected with soluble and insoluble portions of rabbit bone. No circulating antibody could be detected by binding of radioiodinated gamma globulin, erythrocyte hemagglutination, or agar-gel diffusion.

Insignificant differences in properdin titer were observed in rabbit sera following experimentally produced fractures, autografts, and homografts.


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