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Journal of Bone and Joint Surgery, 1959;41:1149-1156.
© 1959 by The Journal of Bone and Joint Surgery, Inc

Histological and Alkaline-Phosphatase Changes in Autogenous Transplants of Tibial Grafts in Dogs Treated with Cortisone

Edgar A. Tonna PH.D.1 and James A. Nicholas M.D.1

1 Department of Research, Hospital for Special Surgery, New York

Cortisone treatment of dogs after transplants of autogenous tibial grafts revealed sharply reduced alkaline-phosphatase activity two and four weeks after surgery. Graft incorporation and suitable trabecular formation were not seen until four weeks after transplantation in corticosteroid-treated dogs; the trabeculae of the callus lacked the usual osteoblastic lining. Histologically and grossly, the graft site in cortisone-treated dogs exhibited a retardation in bone healing of two weeks when compared with that in control dogs.


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