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Journal of Bone and Joint Surgery, 1959;41:152-166.
© 1959 by The Journal of Bone and Joint Surgery, Inc

Assay of Foreign-Body Reaction

Jonathan Cohen M D.1

1 Departments of Orthopaedic Surgery and Pathology, Harvard Medical School and Children's Medical Center, and the Division of Laboratories and Research, Children's Medical Center, Boston

1. A method is described for comparison of metallic substances with reference to their capacity to evoke inflammation when used subcutaneously.

2. Powders of the test metal may be compared with similar powders of other umetals by injecting suspensions of them into animals and examining the histological reaction at intervals.

3. By this method, very fine powders of several substances including type 316 stainless steel, and a cobalt chromium alloy were compared. All showed some degree of reaction, the least being evoked by the cobalt chrome alloy.


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