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Journal of Bone and Joint Surgery, 1958;40:1103-1110.
© 1958 by The Journal of Bone and Joint Surgery, Inc

The Effect of Pressor and Depressor Drugs on Intramedullary Bone-Marrow Pressure

ARTHUR H. STEIN JR. M.D.1, HARRY C. MORGAN M.D.1, and ROBERTO F. PORRAS M.D.1

1 Orthopaedic Division of the Department of Surgery, Washington University School of Medicine, St. Louis

1. Intramedullary bone-marrow pressure levels are dependent upon the systemic-blood pressure and the patency of the nutrient artery and possibly other smaller vessels.

2. Intramedullary pressure may be lowered by simultaneously lowering systemic-blood pressure by injection of histamine. The marrow pressure can be increased simultaneously with the systemic pressure by amphetamine.

3. Intramedullary pressure may be lowered while there is a simultaneous rise in the systemic-blood pressure. Adrenalin, nor-epinephrine, and pituitrin produce the response.

4. From the evidence presented, it is believed that the major effect of adrenalin, nor-epinephrine, and pituitrin is produced locally and is independent of systemic-blood pressure. The marked fall in marrow pressure following injection of adrenalin and nor-epinephrine is probably due to vasoconstriction of the nutrient vessels.


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