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Journal of Bone and Joint Surgery, 1958;40:1093-1102.
© 1958 by The Journal of Bone and Joint Surgery, Inc

Fracture Healing in Rats Treated with Aminoacetonitrile

IGNACIO V. PONSETI M.D.1 and FERNANDO ALEU M.D.1

1 Departments of Orthopaedic Surgery and Pathology, State University of Iowa, Iowa City

Aminoacetonitrile administered to adult rats with experimental fractures induced the formation of a voluminous fibrocartilaginous callus which ossified well during the second week of fracture. This callus became very osteoporotic during the third week, and bone union usually did not occur.

When aminoacetonitrile was administered only during the first week after fracture, callus slightly larger than that in the control animals developed with speedier bone union.

In rats treated with l-triiodothyronine alone, fracture callus, apparently similar to that of the controls, developed.

When l-triiodothyronine was administered simultaneously with aminoacetonitrile, fracture callus, smaller and better ossified than that in animals treated with amioacetonitrile alone, formed.


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