THE PATHOLOGY OF OSTEITIS DEFORMANS, PAGET'S DISEASE

¹ The Pathological Laboratory of the University of Maryland.

We have, then, osteoporosis with disappearance of bone by lacunar absorption and chemical (vital fluid?) dissolution, accompanied by new formation of bone. In my case the new formation is not so marked as in those reported by others. The active process seems to have been completed.

There is evidence of breaking down of bone—I would say bending of trabeculae crushing down on neighboring cancelli, obliterating some canals and assisting in the formation of others.

There is marked vascular degeneration with varicose vessels, thrombosis, congestion, leakage with edema and minute hemorrhages. The surrounding tissues are modified to a certain extent as evidenced by changes in vessels, nerves, muscles, and tendons. It is suggested that this is due to the bone absorption in their neighborhood throwing them in contact with unaccustomed (unusual) neighboring material. In the case of muscle attachments the distortion and microscopical changes are especially marked.

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