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Journal of Bone and Joint Surgery, 1957;39:1198-1202.
© 1957 by The Journal of Bone and Joint Surgery, Inc

Eight Cases of Hereditary Bilateral Medial Tibial Torsion in Four Generations

JOHANNA BLUMEL PH.D.1, G. W. N. EGGERS M.D.1, and E. BURKE EVANS M.D.1

1 Orthopaedic Division, Department of Surgery, University of Texas Medical Branch, Galveston

Multiple marriages in this pedigree strengthen the evidence of a genetic basis for the inheritance of torsion. The apparent progenitor (I-1) was married twice, transmitting the abnormality to offspring of both marriages. Two later marriages of the mate of II-1 substantiate this conclusion, since none of the progeny of these two unions show the trait.

Examination of Chart I reveals that only those individuals possessing the trait transmit it to their offspring; that the trait manifests itself in every generation; that approximately one-half of the total number of individuals in the family are affected; and that the abnormality affects males and females alike.

A Mendelian autosomal dominant type of inheritance is demonstrated for bilateral medial tibial torsion in this pedigree.


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