This Article
Right arrow Full Text (PDF)
Right arrow Letters to the Editor: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when Letters to the Editor are posted
Right arrow Alert me if a correction is posted
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My File Cabinet
Right arrow Download to citation manager
Right arrowReprints and Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by RAY, R. D.
Right arrow Articles by HOLLOWAY, J. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by RAY, R. D.
Right arrow Articles by HOLLOWAY, J. A.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Technorati  
What's this?
Journal of Bone and Joint Surgery, 1957;39:1119-1128.
© 1957 by The Journal of Bone and Joint Surgery, Inc

Bone Implants

Preliminary Report of an Experimental Study

ROBERT D. RAY M.D., PH.D.1 and JON A. HOLLOWAY M.D.1

1 University of Washington School of Medicine, Seattle

Of the various materials used, it would appear that the best substitute for fresh autogenous-bone grafts (if mechanical factors are not a consideration) is the organic matrix of bone devoid of its inorganic salt. This conclusion, incidentally, is not new. Nicholas Senn came to the same conclusion in 1889 on the basis of a series of experiments in which filled bone defects with heterogenous bone previously treated with dilute hydrochloric acid. To quote Senn : "Antiseptic decalcified bone is the best substitute for living bone grafts and the restoration of loss of substance in bone . . . [such a] packing furnished the best medium for the growth and development of the tissue resulting from the regenerative process initiated by the trauma." Miller, in a clinical report in 1890, stated that pieces of ox ribs, decalcified with dilute hydrochloric acid and sterilized by soaking in dilute carbolic acid, appeared to be superior to fresh bone in obtaining repair of a tibial defect.

Apparently successful replacement of an implant depends on the readiness with which it can be invaded by vascular elements. The presence of inorganic salts in the implant would appear to impede rather than accelerate the process of replacement. In this connection Cohen, Maletskos, Marshall, and Williams reported that a study of the fate of bone grafts by means of radioactive tracers revealed that all of the calcium incorporated into the callus came by way of the circulating blood from skeletal sources situated throughout the body rather than through diffusion from the graft. Whether any antigenic factors are present in decalcified matrix implants or whether the organic matrix can be further fractionated has not yet been determined.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 JBJSHome page
T. R. HUNT, J. R. SCHWAPPACH, and H. C. ANDERSON
Healing of a Segmental Defect in the Rat Femur with Use of an Extract from a Cultured Human Osteosarcoma Cell-Line (Saos-2). A Preliminary Report
J. Bone Joint Surg. Am., January 1, 1996; 78(1): 41 - 8.
[Abstract] [Full Text]

Home page
 ScienceHome page
M. R. Urist
Bone: Formation by Autoinduction
Science, November 12, 1965; 150(3698): 893 - 899.
[Abstract] [PDF]