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Journal of Bone and Joint Surgery, 1955;37:1028-1034.
© 1955 by The Journal of Bone and Joint Surgery, Inc

METABOLIC STUDIES OF CHILDREN WITH IDIOPATHIC SCOLIOSIS

Genevieve Stearns Ph.D.1, Jo-Yun Tung Chen Ph.D.1, John B. McKinley M.S.1, and Ignacio V. Ponseti M.D.1

1 Departments of Pediatrics and Orthopaedics, College of Medicine, State University of Iowa, Iowa City

Metabolic studies of calcium, phosphorus, and nitrogen in children with moderate to severe idiopathic scoliosis have been carried out. The findings demonstrated no clear-cut abnormality in mineral metabolism, but did show a serious disturbance in catabolism of protein with excessive wastage of nitrogen through the urine. The metabolic error also appears to involve derivatives of sulphur-containing amino acids. The scoliotic children tended to excrete a larger number of essential amino acids than did normal children of the same age range.


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