Journal of Bone and Joint Surgery, 1952;34:211-214.
© 1952 by The Journal of Bone and Joint Surgery, Inc
ARTHROGRYPOSIS MULTIPLEX CONGENITA IN TWINS
J. W. HILLMAN M.D.1 and
J. T. H. JOHNSON M.D.1
1 Department of Surgery, Division of Orthopaedic Surgery, The Johns Hopkins Hospital and The Johns Hopkins School of Medicine, Baltimore
Two sets of twins are presented, in which one child in each set has arthrogryposis multiplex congenita and the other child in each set is entirely normal. These are sets of identical twins, as demonstrated by both clinical and serological data. The disease in these instances could not have been genetically produced, since there is no deformity in the monozygotic twin. Doubt is expressed whether maternal infection or intra-uterine environment could affect one child and not the other. No current concept of etiology adequately accounts for the manifestations of the disease.