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Journal of Bone and Joint Surgery, 1951;33:863-888.
© 1951 by The Journal of Bone and Joint Surgery, Inc

THE PRESERVATION AND CLINICAL USE OF FREEZE-DRIED BONE

F. P. KREUZ 1, G. W. HYATT 1, THOMAS C. TURNER 1, and ANDREW L. BASSETT 1

1 Naval MedicaL School, Naval Medical Research Institute, and Naval Hospital National Naval Medical Center, Bethesda, Maryland

1. Freeze-dried homogenous bone grafts measuring 6 to 8 centimeters by 0.5 to 1.0 centimeter were grafted into the radii of dogs. It was found that they were incorporated in the same manner as fresh autogenous bone grafts but at a slightly slower rate. The freeze-dried bone was somewhat superior to frozen bone in regard to the rate of healing in the early phases.

2. Except for the previously mentioned variations in the rate of healing, all the grafts were incorporated in a manner roughhy comparable to the healing of the bone defect of the same size in which grafts were not inplanted.

3. The advantages of storage at room temperatures, the potentiallY increased storage periods, the case of transportation, and initial clinical success suggest that freeze-dried homogenous bone is suitable for use in bone banks.


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