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Journal of Bone and Joint Surgery, 1951;33:265-267.
© 1951 by The Journal of Bone and Joint Surgery, Inc

NOTE ON THE USE OF NITROGEN MUSTARD IN RHEUMATOID ARTHRITIS

With Consideration of the Similarity of Its Effect to That of Cortisone and ACTH

NED M. SHUTKIN M.D.1

1 Orthopaedic Division, Department of Surgery, Duke University School of Medicine, Durham

1. Six patients with active rheumatoid arthritis showed prompt, but transient, improvement after the administration of nitrogen mustard.

2. Nitrogen mustard produces depletion of the cholesterol esters and ascorbic acid of the adrenal cortex in the experimental animal.

3. ACTH produces depletion of the cholesterol esters and ascorbic acid of the adrenal cortex.

4. Further investigation to determine the efficacy of nitrogen mustard in the treatment of rheumatoid arthritis is indicated.


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