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Journal of Bone and Joint Surgery, 1948;30:500-505.
© 1948 by The Journal of Bone and Joint Surgery, Inc

THE pH OF THE SYNOVIAL FLUID IN THE ANAESTHETIZED DOG UNDER TREATMENT WITH METRAZOL OR INSULIN

Irving E. Steck M.D.1, Norman R. Joseph Ph.D.1, and C. I. Reed Ph.D.1

1 Departments of Medicine and Physiology, University of Illinois, Chicago Professional Colleges, Chicago

This paper reports the results of alterations in the pH of synovial fluid and of blood of dogs anaesthetized with nembutal, in response to agents producing extreme muscle activity.

The intravenous administration of metrazol, in doses producing convulsions, resulted in a more pronounced decrease in the pH of synovial fluid than in that of blood. This difference was progressively developed to a maximum stage somewhat later than in blood.

The injection of insulin produced similar, but less pronounced, results, although the graphs were less smooth and regular and there was better correlation between the alterations of pH in the two fluids.


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