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Journal of Bone and Joint Surgery, 1943;25:644-646.
© 1943 by The Journal of Bone and Joint Surgery, Inc

THE EXPERIMENTAL USES OF THE SULFONAMIDES AND OTHER DRUGS IN ACUTE PURULENT ARTHRITIS

Charles J. Frankel M.D.1 and N. W. Larkum M.D.1

1 Departments of Orthopaedic Surgery and Bacteriology, University of Virginia Medical School, Charlottesville

In view of what is known to date of the action of the sulfonamide drugs, the inhibiting effect of purulent material, and of the bacteriostatic rather than the bactericidal properties against staphylococcus, the authors believe they are justified in drawing the following conclusions:

1. In cases of marked infection, the sulfonamide drugs and other therapeutic agents cannot alone be expected to control the infection.

2. Surgical procedures are as necessary today as before. The drugs are extremely valuable as adjuncts, but the authors can find no good evidence to support any contention that they can be expected to control bone and joint infections.


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