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Journal of Bone and Joint Surgery, 1943;25:553-565.
© 1943 by The Journal of Bone and Joint Surgery, Inc

BONE CHANGES IN ACUTE AND CHRONIC SCURVY

An Experimental Study

Sam W. Banks M.D.1

1 Department of Surgery, Division of Orthopaedic Surgery, University of Chicago, Chicago

1. Protracted scurvy in guinea pigs is characterized by a suppression of the entire growth zone leading eventually to complete cessation of enchondral ossification in animals whose ascorbic-acid intake is sufficiently restricted.

2. Calcified cartilage columns do not accumulate in the metaphysis as a "lattice" in guinea pigs as, according to the report of Park, Guild, Jackson, and Bond, they do in human cases of protracted scurvy.

3. The activity of osteoblasts and chondroblasts is suppressed, partly or completely, according to the vitamin-C intake. In early acute lesions of chronic scurvy, osteoblasts are present in increased numbers, but do not lay down bone.


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