TREATMENT OF GAS GANGRENE EXPERIMENTALLY PRODUCED

¹ NEW ORLEANS, LOUISIANA

An effort has been made to produce experimentally, in guinea pigs, the counterpart of a compound fracture infected with a lethal number of Welch's bacilli, and to treat these in some of the various ways suggested by clinical and laboratory observations.

Débridement of the wounds followed by implantation of 15 to 30 milligrams of sulfanilamide crystals and closure resulted in the survival of only four of nineteen animals.

Débridement and irrigation of similar wounds left open, and followed by the administration of 50 milligrams of sulfanilamide intraperitoneally every six hours, resulted in the survival of seven of nine animals.

Débridement and irrigation of such wounds followed by implantation of zinc peroxide paste and suture of the wounds resulted in the survival of four of five animals.

Wounds similarly produced and sutured and treated with roentgen rays in varying dosage at different intervals were followed by death in seven of ten animals.

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