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Journal of Bone and Joint Surgery, 1937;19:891-903.
© 1937 by The Journal of Bone and Joint Surgery, Inc

THE INFECTIOUS ORGANISM IN OSTEOMYELITIS

Part II. Bacteriophage and Serum Therapy

WARD J. MacNEAL M.D.1

1 The Department of Pathology and Bacteriology, New York Post-Graduate Medical School and Hospital, Columbia University

1. The filterable agent of transmissible bacteriolysis causes solution of the respective bacteria in watery culture media. In the circulating blood of the living animal it apparently fails to cause such solution, but exerts an opsonic effect, favoring more effective phagocytosis.

2. When properly employed, such a lytic agent brings aid to the body defenses in overcoming infection with the staphylococcus, not only in furuncles, carbuncles, and septicaemia, but also in the bone lesions of staphylococcic osteomyelitis.

3. Staphylococci have been observed within polynuclear neutrophilic leukocytes of the circulating blood.


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