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Journal of Bone and Joint Surgery, 1937;19:630-639.
© 1937 by The Journal of Bone and Joint Surgery, Inc

SERUM PHOSPHATASE—ITS CLINICAL APPLICATION IN DISEASES OF BONE

C. LESLIE MITCHELL M.D.1 and ROBERT R. CRAWFORD M.D.1

1 Henry Ford Hospital

1. In reviewing the relation of serum-phosphatase activity to the more common diseases of bone, it has been found, in general, that there is an increase in serum-phosphatase activity accompanying the formation of unusual amounts of new or of abnormal bone. There appears to be little or no increase associated with the purely destructive lesion of bone.

2. Determinations of serum phosphatase are an important aid in the diagnosis and differential diagnosis of Paget's disease, osteitis fibrosa cystica, and tumors of bone.

3. The level of serum-phosphatase activity cannot be used as an index of healing or of the ability of a fracture to heal.

4. No significant changes in serum-phosphatase activity were noted in cases of bone and joint tuberculosis and of osteomyelitis.

5. Serial phosphatase determinations are suggested as a criterion of effective therapy in Paget's disease, hyperparathyroidism, osteoblastic osteogenic sarcoma, and rickets.


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